Richard Madden and Priyanka Chopra Jonas star in the Prime Video series “Citadel.” (Courtesy of Prime Video)

“Citadel” begins with an inverted camera shot, suggesting to viewers they are in for a disorienting ride.

The expensive and reasonably entertaining new science-fiction-tinged spy series from Prime Video — debuting with its first two episodes this week, before releasing its four remaining first-season installments weekly — continues to suggest this after flipping to the standard orientation.

Executive produced by Mayfield Village natives and Hollywood heavyweights Joe and Anthony Russo, “Citadel” places us aboard a passenger train, on which we meet two agents of the series’ namesake global spy agency, Richard Madden’s Mason Kane and Priyanka Chopra Jonas’ Nadia Sinh. They exchange some flirtatious banter, as well as a kiss to maintain their cover, before he excuses himself to fight another man in a restroom and she corners their target at a nearby table.

“What are you, CIA?” the man asks her. “MI6?”

“Do I look like a woman who plays for the minor leagues?” Nadia responds.

In fact, he knows full well that she’s Citadel.

Thought to be carrying uranium, the man instead is part of an expansive plot by the nefarious organization Manticore to bring down Citadel. It is, unfortunately for the world, an effort that proves to be successful.

Nadia and Mason escape the train with their lives. But not, as it turns out, with their memories.

The main narrative of “Citadel” is set eight years later, with the separated super agents living civilian lives with new identities and with virtually no recollections about their dangerous former lives. Of course, they soon will be brought back together, with the help of former Citadel colleague Bernard Orlick (Stanley Tucci) to keep a highly sensitive briefcase from falling into Manticore’s hands.

Running point for Manticore is Dahlia Archer (Lesley Manville), who has her seemingly clean hands in world affairs thanks to her job as the British ambassador to the United States. As one would expect of such a villain, she apparently will stop at nothing to acquire said case.